Spicy Cajun Chicken Alfredo

Featured in: Quick Snack Bites

This dish pairs tender chicken breasts coated in bold Cajun seasoning with creamy Alfredo sauce, tossed through perfectly cooked fettuccine. Garlic, smoked paprika, and a touch of chili flakes add depth and subtle heat, while fresh parsley and extra Parmesan elevate the flavors. The sauce is silky smooth, balanced with reserved pasta water to achieve the ideal consistency. Ready in just 40 minutes, it’s a satisfying main course for lovers of creamy and spicy combinations.

Updated on Sat, 15 Nov 2025 11:19:00 GMT
Creamy Spicy Cajun Chicken Alfredo over fettuccine, a flavorful, satisfying pasta dinner at its finest. Save
Creamy Spicy Cajun Chicken Alfredo over fettuccine, a flavorful, satisfying pasta dinner at its finest. | fryzia.com

A bold creamy pasta dish featuring tender Cajun spiced chicken tossed with fettuccine in a rich Alfredo sauce perfect for spice lovers.

I first made this Spicy Cajun Chicken Alfredo to surprise my family who adore both Cajun and Italian flavors and it quickly became a weeknight favorite in our house.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 2 tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 340 g (12 oz) fettuccine
  • Alfredo Sauce: 2 tablespoons unsalted butter 3 cloves garlic minced 1 cup (240 ml) heavy cream 1 cup (100 g) freshly grated Parmesan cheese 1/2 teaspoon smoked paprika 1/2 teaspoon chili flakes (optional for extra heat) Salt and black pepper to taste
  • Garnishes: 2 tablespoons chopped fresh parsley Extra grated Parmesan cheese

Instructions

Cook the Pasta:
Cook the fettuccine according to package instructions in salted boiling water until al dente Reserve 1/2 cup pasta water then drain and set aside
Season and Cook Chicken:
Pat chicken breasts dry and coat them evenly with Cajun seasoning Heat olive oil in a large skillet over medium high heat Add chicken and cook 5 6 minutes per side or until fully cooked and golden brown Remove chicken from the skillet let rest for 5 minutes then slice thinly
Make Alfredo Sauce:
In the same skillet reduce heat to medium and add butter Sauté minced garlic for 1 minute until fragrant Stir in heavy cream smoked paprika and chili flakes Bring to a gentle simmer then whisk in Parmesan cheese until melted and sauce is smooth Season with salt and pepper
Toss Pasta and Finish:
Add cooked fettuccine to the sauce tossing to coat If needed add reserved pasta water a little at a time for a silkier sauce
Serve:
Top pasta with sliced Cajun chicken Garnish with chopped parsley and extra Parmesan Serve immediately
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| fryzia.com

Every time I serve this pasta my kids always ask for seconds and even our pickiest eater loves the spicy creamy sauce.

Required Tools

Large pot large skillet tongs chefs knife cutting board measuring cups and spoons

Allergen Information

Contains dairy cream butter Parmesan Contains gluten fettuccine May contain allergens in Cajun seasoning always check for mustard or celery Always check labels for potential allergen cross contamination

Nutritional Information

Per serving Calories 610 Total Fat 27 g Carbohydrates 54 g Protein 38 g

Tender Cajun-spiced chicken atop rich Alfredo with fettuccine, a spicy and delicious Spicy Cajun Chicken Alfredo. Save
Tender Cajun-spiced chicken atop rich Alfredo with fettuccine, a spicy and delicious Spicy Cajun Chicken Alfredo. | fryzia.com

This bold spicy Cajun Alfredo is delicious straight from the pan and is sure to become a dinner favorite in your home.

Recipe FAQ Section

How can I make the Alfredo sauce creamier?

Adding reserved pasta water gradually helps achieve a silkier and creamier sauce consistency.

What cut of chicken works best for this dish?

Boneless, skinless chicken breasts are ideal as they cook evenly and remain tender when sliced.

Can I adjust the spice level?

Yes, increasing Cajun seasoning or chili flakes will boost the heat to your preference.

Is there a substitute for fettuccine pasta?

Penne or linguine can be used as alternatives, offering different textures but similar cooking times.

What garnishes enhance flavor?

Fresh chopped parsley and extra grated Parmesan add freshness and a savory finish.

Spicy Cajun Chicken Alfredo

Creamy fettuccine with tender Cajun-spiced chicken in a rich, spicy Alfredo sauce.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Samantha Rivera

Classification Quick Snack Bites

Complexity Level Medium

Heritage American

Output 4 Portion Count

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/2 teaspoon smoked paprika
06 1/2 teaspoon chili flakes (optional)
07 Salt and black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Preparation Steps

Phase 01

Cook Pasta: Boil salted water and cook fettuccine according to package directions until al dente. Reserve 1/2 cup of pasta water, then drain and set aside.

Phase 02

Prepare Chicken: Pat chicken breasts dry and evenly coat with Cajun seasoning.

Phase 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until fully cooked and golden brown. Remove and let rest for 5 minutes, then slice thinly.

Phase 04

Make Alfredo Sauce: Reduce heat to medium in the same skillet. Add butter and sauté minced garlic for 1 minute until fragrant. Stir in heavy cream, smoked paprika, and chili flakes, simmer gently. Whisk in Parmesan cheese until smooth. Season with salt and pepper.

Phase 05

Combine Pasta and Sauce: Add cooked fettuccine to the sauce and toss to coat thoroughly. Add reserved pasta water gradually to achieve a silky consistency if needed.

Phase 06

Serve: Top pasta with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan cheese. Serve immediately.

Necessary tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy information

Review all ingredients for potential allergens and consult with healthcare providers if you're uncertain about any item.
  • Contains dairy, gluten, and possible mustard or celery from Cajun seasoning. Verify ingredient labels for allergen cross-contamination.

Nutrient breakdown (per portion)

These values are approximate and shouldn't replace professional medical guidance.
  • Energy Value: 610
  • Fat: 27 g
  • Carbohydrates: 54 g
  • Protein Content: 38 g